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COMMUNITY DETECTION FROM GENOMIC DATASETS ACROSS HUMAN CANCERS

Abstract: 

Cancers originating from different organs can show similar genomic alterations whereas cancers originating from the same organ can vary across patients. Therefore cancer stratification that does not depend on the tissue of the origin can play an important role to better understand cancers having similar genomic patterns irrespective of their origins. In this work, we formulated the problem as a weighted graph and communities were found using a modularity maximization based graph clustering method. We classified 3,199 subjects from twelve different cancer types into five clusters. The five communities show significantly different survival rate curves. The distribution of tumor types against communities shows that lung, colon and rectum adenocarcinoma cluster together, whereas breast and ovarian cancers form another cluster.

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Paper Details

Authors:
Nandinee Haq, Z. Jane Wang
Submitted On:
8 December 2016 - 2:41pm
Short Link:
Type:
Presentation Slides
Event:
Presenter's Name:
Nandinee Haq
Paper Code:
1265
Document Year:
2016
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GlobalSIP.pdf

(135 downloads)

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[1] Nandinee Haq, Z. Jane Wang, "COMMUNITY DETECTION FROM GENOMIC DATASETS ACROSS HUMAN CANCERS", IEEE SigPort, 2016. [Online]. Available: http://sigport.org/1424. Accessed: Oct. 22, 2017.
@article{1424-16,
url = {http://sigport.org/1424},
author = {Nandinee Haq; Z. Jane Wang },
publisher = {IEEE SigPort},
title = {COMMUNITY DETECTION FROM GENOMIC DATASETS ACROSS HUMAN CANCERS},
year = {2016} }
TY - EJOUR
T1 - COMMUNITY DETECTION FROM GENOMIC DATASETS ACROSS HUMAN CANCERS
AU - Nandinee Haq; Z. Jane Wang
PY - 2016
PB - IEEE SigPort
UR - http://sigport.org/1424
ER -
Nandinee Haq, Z. Jane Wang. (2016). COMMUNITY DETECTION FROM GENOMIC DATASETS ACROSS HUMAN CANCERS. IEEE SigPort. http://sigport.org/1424
Nandinee Haq, Z. Jane Wang, 2016. COMMUNITY DETECTION FROM GENOMIC DATASETS ACROSS HUMAN CANCERS. Available at: http://sigport.org/1424.
Nandinee Haq, Z. Jane Wang. (2016). "COMMUNITY DETECTION FROM GENOMIC DATASETS ACROSS HUMAN CANCERS." Web.
1. Nandinee Haq, Z. Jane Wang. COMMUNITY DETECTION FROM GENOMIC DATASETS ACROSS HUMAN CANCERS [Internet]. IEEE SigPort; 2016. Available from : http://sigport.org/1424