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EVENT-RELATED SYNCHRONISATION RESPONSES TO N-BACK MEMORY TASKS DISCRIMINATE BETWEEN HEALTHY AGEING, MILD COGNITIVE IMPAIRMENT, AND MILD ALZHEIMER’S DISEASE

Abstract: 

In this study we investigate whether or not event-related (de)synchronisation (ERD/ERS) can be used to differenti- ate between 27 healthy elderly, 21 subjects diagnosed with amnestic mild cognitive impairment (aMCI) and 16 mild Alzheimer’s disease (AD) patients. Using 32-channel EEG recordings, we measured ERD responses to a three-level vi- sual N-back task (N = 0, 1, 2) on the well-known delta, theta, alpha, beta and gamma bands. Our findings revealed that healthy elderly (HE) elicited consistently greater beta and alpha ERD responses than MCI and AD patients at many scalp electrodes, most of them located at fronto-central and temporal-parietal areas. Additionally, significant ERD dif- ferences were found on the gamma band in the MCI vs. AD comparison. Based on these findings, we conclude that ERD responses to a working memory (N-back) task could be useful for early MCI diagnosis or for improved AD diagnosis, and also for assessing the likelihood of MCI progression to AD.

Index Terms— working memory, event-related (de)synchronisation, mild cognitive impairment, Alzheimer’s disease

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Paper Details

Authors:
Francisco J. Fraga, Leonardo A. Ferreira, Tiago H. Falk, Erin Johns, Natalie D. Phillips
Submitted On:
2 March 2017 - 7:08am
Short Link:
Type:
Presentation Slides
Event:
Presenter's Name:
Francisco J. Fraga
Paper Code:
3050
Document Year:
2017
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ICASSP 2017 Paper #3050 (Francisco J Fraga) - ERD responses to N-back tasks discriminate MCI from Healthy and AD patients

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[1] Francisco J. Fraga, Leonardo A. Ferreira, Tiago H. Falk, Erin Johns, Natalie D. Phillips, "EVENT-RELATED SYNCHRONISATION RESPONSES TO N-BACK MEMORY TASKS DISCRIMINATE BETWEEN HEALTHY AGEING, MILD COGNITIVE IMPAIRMENT, AND MILD ALZHEIMER’S DISEASE", IEEE SigPort, 2017. [Online]. Available: http://sigport.org/1582. Accessed: Jul. 27, 2017.
@article{1582-17,
url = {http://sigport.org/1582},
author = {Francisco J. Fraga; Leonardo A. Ferreira; Tiago H. Falk; Erin Johns; Natalie D. Phillips },
publisher = {IEEE SigPort},
title = {EVENT-RELATED SYNCHRONISATION RESPONSES TO N-BACK MEMORY TASKS DISCRIMINATE BETWEEN HEALTHY AGEING, MILD COGNITIVE IMPAIRMENT, AND MILD ALZHEIMER’S DISEASE},
year = {2017} }
TY - EJOUR
T1 - EVENT-RELATED SYNCHRONISATION RESPONSES TO N-BACK MEMORY TASKS DISCRIMINATE BETWEEN HEALTHY AGEING, MILD COGNITIVE IMPAIRMENT, AND MILD ALZHEIMER’S DISEASE
AU - Francisco J. Fraga; Leonardo A. Ferreira; Tiago H. Falk; Erin Johns; Natalie D. Phillips
PY - 2017
PB - IEEE SigPort
UR - http://sigport.org/1582
ER -
Francisco J. Fraga, Leonardo A. Ferreira, Tiago H. Falk, Erin Johns, Natalie D. Phillips. (2017). EVENT-RELATED SYNCHRONISATION RESPONSES TO N-BACK MEMORY TASKS DISCRIMINATE BETWEEN HEALTHY AGEING, MILD COGNITIVE IMPAIRMENT, AND MILD ALZHEIMER’S DISEASE. IEEE SigPort. http://sigport.org/1582
Francisco J. Fraga, Leonardo A. Ferreira, Tiago H. Falk, Erin Johns, Natalie D. Phillips, 2017. EVENT-RELATED SYNCHRONISATION RESPONSES TO N-BACK MEMORY TASKS DISCRIMINATE BETWEEN HEALTHY AGEING, MILD COGNITIVE IMPAIRMENT, AND MILD ALZHEIMER’S DISEASE. Available at: http://sigport.org/1582.
Francisco J. Fraga, Leonardo A. Ferreira, Tiago H. Falk, Erin Johns, Natalie D. Phillips. (2017). "EVENT-RELATED SYNCHRONISATION RESPONSES TO N-BACK MEMORY TASKS DISCRIMINATE BETWEEN HEALTHY AGEING, MILD COGNITIVE IMPAIRMENT, AND MILD ALZHEIMER’S DISEASE." Web.
1. Francisco J. Fraga, Leonardo A. Ferreira, Tiago H. Falk, Erin Johns, Natalie D. Phillips. EVENT-RELATED SYNCHRONISATION RESPONSES TO N-BACK MEMORY TASKS DISCRIMINATE BETWEEN HEALTHY AGEING, MILD COGNITIVE IMPAIRMENT, AND MILD ALZHEIMER’S DISEASE [Internet]. IEEE SigPort; 2017. Available from : http://sigport.org/1582