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GDSPIKE: AN ACCURATE SPIKE ESTIMATION ALGORITHM FROM NOISY CALCIUM FLUORESCENCE SIGNALS

Abstract: 

Accurate estimation of spike train from calcium (Ca2+) fluorescence signals is challenging owing to significant fluctuations of fluorescence level. This paper proposes a non-model-based approach for spike train inference using group delay (GD) analysis. It primarily exploits the property that change in Ca2+ fluorescence corresponding to a spike can be characterized by an onset, an attack, and a decay. The proposed algorithm, GDspike, is compared with state-of-the-art systems on five datasets. F-measure is best for GDspike (41%) followed by STM (40%), MLspike (39%), and Vogelstein (35%). While existing methods are inspired by the physiology of neuronal responses, the proposed approach is inspired by GD-based high-resolution processing of the Ca2+ fluorescence signal. GDspike is a fast and unsupervised algorithm. It is unaffected by the scanning rate and indicator protein/dye.

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Paper Details

Authors:
Jilt Sebastian, Mari Ganesh Kumar, Y. S. Sreekar, Rajeev Vijay Rikhye, Mriganka Sur, Hema A. Murthy
Submitted On:
7 March 2017 - 1:28pm
Short Link:
Type:
Poster
Event:
Presenter's Name:
JILT SEBASTIAN
Paper Code:
ICASSP1701
Document Year:
2017
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[1] Jilt Sebastian, Mari Ganesh Kumar, Y. S. Sreekar, Rajeev Vijay Rikhye, Mriganka Sur, Hema A. Murthy, " GDSPIKE: AN ACCURATE SPIKE ESTIMATION ALGORITHM FROM NOISY CALCIUM FLUORESCENCE SIGNALS", IEEE SigPort, 2017. [Online]. Available: http://sigport.org/1690. Accessed: May. 30, 2017.
@article{1690-17,
url = {http://sigport.org/1690},
author = {Jilt Sebastian; Mari Ganesh Kumar; Y. S. Sreekar; Rajeev Vijay Rikhye; Mriganka Sur; Hema A. Murthy },
publisher = {IEEE SigPort},
title = { GDSPIKE: AN ACCURATE SPIKE ESTIMATION ALGORITHM FROM NOISY CALCIUM FLUORESCENCE SIGNALS},
year = {2017} }
TY - EJOUR
T1 - GDSPIKE: AN ACCURATE SPIKE ESTIMATION ALGORITHM FROM NOISY CALCIUM FLUORESCENCE SIGNALS
AU - Jilt Sebastian; Mari Ganesh Kumar; Y. S. Sreekar; Rajeev Vijay Rikhye; Mriganka Sur; Hema A. Murthy
PY - 2017
PB - IEEE SigPort
UR - http://sigport.org/1690
ER -
Jilt Sebastian, Mari Ganesh Kumar, Y. S. Sreekar, Rajeev Vijay Rikhye, Mriganka Sur, Hema A. Murthy. (2017). GDSPIKE: AN ACCURATE SPIKE ESTIMATION ALGORITHM FROM NOISY CALCIUM FLUORESCENCE SIGNALS. IEEE SigPort. http://sigport.org/1690
Jilt Sebastian, Mari Ganesh Kumar, Y. S. Sreekar, Rajeev Vijay Rikhye, Mriganka Sur, Hema A. Murthy, 2017. GDSPIKE: AN ACCURATE SPIKE ESTIMATION ALGORITHM FROM NOISY CALCIUM FLUORESCENCE SIGNALS. Available at: http://sigport.org/1690.
Jilt Sebastian, Mari Ganesh Kumar, Y. S. Sreekar, Rajeev Vijay Rikhye, Mriganka Sur, Hema A. Murthy. (2017). " GDSPIKE: AN ACCURATE SPIKE ESTIMATION ALGORITHM FROM NOISY CALCIUM FLUORESCENCE SIGNALS." Web.
1. Jilt Sebastian, Mari Ganesh Kumar, Y. S. Sreekar, Rajeev Vijay Rikhye, Mriganka Sur, Hema A. Murthy. GDSPIKE: AN ACCURATE SPIKE ESTIMATION ALGORITHM FROM NOISY CALCIUM FLUORESCENCE SIGNALS [Internet]. IEEE SigPort; 2017. Available from : http://sigport.org/1690