This paper proposes digital cancellation of nonlinear distortion originating from out-of-band blocking carriers and induced by the analog front-end nonlinearities in direct-conversion receivers (RXs). The cancellation is enabled by employing an additional reference RX for capturing these blockers. In addition, cancellation of mirror-frequency interference is targeted. The feed-forward cancellation of nonlinear distortion is blindly adaptive without any a priori information of the received signal or the nonlinearity characteristics of the RX. The performance of this approach is demonstrated with laboratory RF measurements using state-of-the-art base-station hardware. With the distortion cancellation, blocker tolerance of the RX is improved by 7–8 dB.