This paper presents COT-AD, a comprehensive Dataset designed to enhance cotton crop analysis through computer vision. Comprising over 25,000 images captured throughout the cotton growth cycle, with 5,000 annotated images, COT-AD includes aerial imagery for field-scale detection and segmentation and high-resolution DSLR images documenting key diseases. The annotations cover pest and disease recognition, vegetation, and weed analysis, addressing a critical gap in cotton-specific agricultural datasets. COT-AD supports tasks such as classification, segmentation, image restoration, enhancement, deep generative model-based cotton crop synthesis and early disease management, advancing data-driven crop management.