Henze-Penrose divergence is a non-parametric divergence measure that can be used to estimate a bound on the Bayes error in a binary classification problem. In this paper, we show that a cross- match statistic based on optimal weighted matching can be used to directly estimate Henze-Penrose divergence. Unlike an earlier approach based on the Friedman-Rafsky minimal spanning tree statistic, the proposed method is dimension-independent. The new approach is evaluated using simulation and applied to real datasets to obtain Bayes error estimates.