The paper discusses different aspects in favor of using in-band full-duplex frontends for integrated sensing and communication (ISAC), considered for deployment of future 5G/6G infrastructure. Possible scenarios for practical utilization of the technology are discussed with additional focus on self-interference cancellation issue. An possible system implementation on abstract level is presented for cellular communication scenario. The main contribution of the paper is to highlight the hardware realization challenges and potential solutions, that can mitigate additional signal processing overheads for ISAC systems.