We introduce the notion of semantic background subtraction, a novel framework for motion detection in video sequences. The key innovation consists to leverage object-level semantics to address the variety of challenging scenarios for background subtraction. Our framework combines the information of a semantic segmentation algorithm, expressed by a probability for each pixel, with the output of any background subtraction algorithm to reduce false positive detections produced by illumination changes, dynamic backgrounds, strong shadows, and ghosts. In addition, it maintains a fully semantic background model to improve the detection of camouflaged foreground objects. Experiments led on the CDNet dataset show that we managed to improve, significantly, almost all background subtraction algorithms of the CDNet leaderboard, and reduce the mean overall error rate of all the 34 algorithms (resp. of the best 5 algorithms) by roughly 50% (resp. 20%).