Sorry, you need to enable JavaScript to visit this website.

facebooktwittermailshare

Sparse Reconstruction for Fluorescence Lifetime Imaging Microscopy with Poisson Noise

Abstract: 

We present a novel, three-stage method to solve the fluorescence lifetime imaging problem under low-photon conditions. In particular, we reconstruct the fluorophore concentration along with its support and fluorescence lifetime from the time-dependent measurements of scattered light exiting the domain. Because detectors used for these problems are photon counting devices, measurements are corrupted by Poisson noise. Consequently, we explicitly consider Poisson noise in conjunction with SPIRAL-$\ell_p$ -- a sparsity-promoting nonconvex optimization method -- to solve this problem. We demonstrate the effectiveness of the proposed three-stage method through numerical experiments in 2D fluorescence lifetime imaging.

up
0 users have voted:

Paper Details

Authors:
Lasith Adhikari, Arnold D. Kim, Roummel F. Marcia
Submitted On:
7 December 2016 - 10:28am
Short Link:
Type:
Poster
Event:
Presenter's Name:
Lasith Adhikari
Document Year:
2016
Cite

Document Files

FLIM with Poisson

(2119)

Keywords

Additional Categories

Subscribe

[1] Lasith Adhikari, Arnold D. Kim, Roummel F. Marcia, "Sparse Reconstruction for Fluorescence Lifetime Imaging Microscopy with Poisson Noise", IEEE SigPort, 2016. [Online]. Available: http://sigport.org/1406. Accessed: Jul. 20, 2019.
@article{1406-16,
url = {http://sigport.org/1406},
author = {Lasith Adhikari; Arnold D. Kim; Roummel F. Marcia },
publisher = {IEEE SigPort},
title = {Sparse Reconstruction for Fluorescence Lifetime Imaging Microscopy with Poisson Noise},
year = {2016} }
TY - EJOUR
T1 - Sparse Reconstruction for Fluorescence Lifetime Imaging Microscopy with Poisson Noise
AU - Lasith Adhikari; Arnold D. Kim; Roummel F. Marcia
PY - 2016
PB - IEEE SigPort
UR - http://sigport.org/1406
ER -
Lasith Adhikari, Arnold D. Kim, Roummel F. Marcia. (2016). Sparse Reconstruction for Fluorescence Lifetime Imaging Microscopy with Poisson Noise. IEEE SigPort. http://sigport.org/1406
Lasith Adhikari, Arnold D. Kim, Roummel F. Marcia, 2016. Sparse Reconstruction for Fluorescence Lifetime Imaging Microscopy with Poisson Noise. Available at: http://sigport.org/1406.
Lasith Adhikari, Arnold D. Kim, Roummel F. Marcia. (2016). "Sparse Reconstruction for Fluorescence Lifetime Imaging Microscopy with Poisson Noise." Web.
1. Lasith Adhikari, Arnold D. Kim, Roummel F. Marcia. Sparse Reconstruction for Fluorescence Lifetime Imaging Microscopy with Poisson Noise [Internet]. IEEE SigPort; 2016. Available from : http://sigport.org/1406