Existing SISR (single image super-resolution) methods mostly assume that a low-resolution (LR) image is bicubicly downsampled from its high-resolution (HR) counterpart, which inevitably give rise to poor performance when the degradation is out of assumption. To address this issue, we propose a framework PRED (parallel residual and encoder-decoder network) with an innovative training strategy to enhance the robustness to multiple degradations. Consequently, the network can handle spatially variant degradations, which significantly improves the practicability of the proposed method. Extensive experimental results on real LR images show that the proposed method can not only produce favorable results on multiple degradations, but also reconstruct visually plausible HR images.