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Image noise can often be accurately fitted to a Poisson-Gaussian distribution. However, estimating the distribution parameters from a noisy image only is a challenging task. Here, we study the case when paired noisy and noise-free samples are accessible. No method is currently available to exploit the noise-free information, which may help to achieve more accurate estimations. To fill this gap, we derive a novel, cumulant-based, approach for Poisson-Gaussian noise modeling from paired image samples.