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Monitoring sleep quality and status is important to learn health condition for improvement and prevent sleep apnea. A bed-mounted seismometer system is proposed to monitor the heart and respiratory rates, and body movement and posture, during the sleep. To effectively monitor sleep status, an innovative local maxima statistics based approach and an instantaneous property based method are developed to estimate heart and respiratory rates, respectively. These methods are more robust and stable compared to previous works.

Time-lapse microscopy provides 4D imaging data for monitoring and studying down to single-cell, the stochastic processes involved as bacterial colonies grow and interact under different stress conditions. Two main factors prevent high throughput analysis: a) cell segmentation and tracking are very time-consuming and error-prone and b) analytics tools are lacking to interpret the plethora of features extracted from a complex “cell-movie.” To address both limitations, we have recently developed a multi-resolution Bio-image Analysis & Single-Cell Analytics framework, called BaSCA.

In this work we analyze the impact of denoising, contrast and edge enhancement using the Deceived Non Local Means (DNLM) filter in a Convolutional Neural Network (CNN) based approach for age estimation using digital X-ray images from hands. The DNLM filter contains two parameters which control edge enhancement and denoising. Increasing levels were tested to assess the impact of both contrast enhancement and denoising in the CNN based model regression accuracy.

Optical coherence tomography (OCT) is a powerful method for imaging the retinal layers. In this paper, we develop a novel 3D fully convolutional deep architecture for automated segmentation of retinal layers in OCT scans. This model extracts features from both the spatial and the inter-frame dimensions by performing 3D convolutions, thereby capturing the information encoded in multiple adjacent frames.

The identification of useful temporal dependence structure in discrete time series data is an important component of algorithms applied to many tasks in statistical inference and machine learning, and used in a wide variety of problems across the spectrum of biological studies. Most of the early statistical approaches were ineffective in practice, because the amount of data required for reliable modelling grew exponentially with memory length.

Geo-tagging images of interest is increasingly important to law enforcement, national security, and journalism. Many images today do not carry location tags that are trustworthy and resilient to tampering; and the landmark-based visual clues may not be readily present in every image, especially in those taken indoors. In this paper, we exploit an invisible signature from the power grid, the Electric Network Frequency (ENF) signal, which can be inherently recorded in a sensing stream at the time of capturing and carries useful location information.

Mass spectrometry (MS) is a fundamental technology of analytical chemistry for measuring the structure of molecules, with many application fields such as clinical biomarker analysis or pharmacokinetics. In the context of proteomic analysis with MS, the superposition of the isotopic patterns of different proteins, in various charge-states produces MS spectra difficult to decipher. The complexity of the pattern models and the large size of the data again increase the difficulty of the analysis step.