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Various protocols have been developed to improve the success rate of In Vitro Fertilization (IVF). Earlier protocols were based on embryonic cell quality on embryos' third day. Newer protocols rely on the blastocyst quality (day-5 embryo).
Artificial intelligence (AI) systems for automatic human embryo quality assessment seem to be the natural trend towards improving IVF's outcome. AI systems can potentially reveal hidden relationships between embryos' various attributes. To this date, most AI systems assess single blastocyst images.

The remarkable performance of deep neural networks (DNNs) currently makes them the method of choice for solving linear inverse problems. They have been applied to super-resolve and restore images, as well as to reconstruct MR and CT images. In these applications, DNNs invert a forward operator by finding, via training data, a map between the measurements and the input images. It is then expected that the map is still valid for the test data. This framework, however, introduces measurement inconsistency during testing.

Computer Aided Diagnosis (CAD) systems are increasingly utilizing image analysis and Deep Learning (DL) techniques, due to their high accuracy in several medical imaging fields, including the detection of Acute Lymphoblastic (or Lymphocytic) Leukemia (ALL) from peripheral blood samples. However, no method in the literature has specifically analyzed the focus quality of ALL images or proposed a technique for sharpening the samples in an adaptive way for the purpose of classification.