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Electroencephalography (EEG) has been widely used in human brain research. Several techniques in EEG relies on analyzing the topographical distribution of the data. One of the most common analysis is EEG microstate (EEG-ms). EEG-ms reflects the stable topographical representation of EEG signal lasting a few dozen milliseconds. EEG-ms were associated with resting state fMRI networks and were associated with mental processes and abnormalities.

Functional connectivity analysis by detecting neuronal coactivation in the brain can be efficiently done using Resting State Functional Magnetic Resonance Imaging (rs-fMRI) analysis. Most of the existing research in this area employ correlation-based group averaging strategies of spatial smoothing and temporal normalization of fMRI scans, whose reliability of results heavily depends on the voxel resolution of fMRI scan as well as scanning duration. Scanning period from 5 to 11 minutes has been chosen by most of the studies while estimating the connectivity of brain networks.

Brain tumor can be a fatal disease in the world. With the aim of improving survival rates, many computerized algorithms have been proposed to assist the pathologists to make a diagnosis, using Whole Slide Pathology Images (WSI). Most methods focus on performing patch-level classification and aggregating the patch-level results to obtain the image classification. Since not all patches carry diagnostic information, it is thus important for our algorithm to recognize discriminative and non-discriminative patches.

Numerous recent papers have demonstrated the utility of graph theoretical analysis in conjunction with sparse inverse covariance estimation (SICE) in understanding the modulation of brain connectivity associated with neuropathology. These concepts may complement established knowledge of functional covariance obtained using principal component analysis (PCA) that can reduce whole data representations of brain data to essential disease specific patterns.

Detection of cell nuclei in microscopic images is a challenging research topic, because of limitations in cellular image quality and diversity of nuclear morphology, i.e. varying nuclei shapes, sizes, and overlaps between multiple cell nuclei. This has been a topic of enduring interest with promising recent success shown by deep learning methods. These methods train for example convolutional neural networks (CNNs) with a training set of input images and known, labeled nuclei locations. Many of these methods are supplemented by spatial or morphological processing.

We propose a new multiclass weighted loss function for instance segmentation of cluttered cells. We are primarily motivated by the need of developmental biologists to quantify and model the behavior of blood T-cells which might help us in understanding their regulation mechanisms and ultimately help researchers in their quest for developing an effective immunotherapy cancer treatment.

We present a region based method for segmenting and splitting
images of cells in an automatic and unsupervised manner.
The detection of cell nuclei is based on the Bradley’s method.
False positives are automatically identified and rejected based
on shape and intensity features. Additionally, the proposed
method is able to automatically detect and split touching cells.
To do so, we employ a variant of a region based multi-ellipse
fitting method (DEFA) that makes use of constraints on the