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We present a novel deep learning-based framework: Embedded Feature Similarity Optimization with Specific Parameter Initialization (SOPI) for 2D/3D medical image registration which is a most challenging problem due to the difficulty such as dimensional mismatch, heavy computation load and lack of golden evaluation standard. The framework we design includes a parameter specification module to efficiently choose initialization pose parameter and a fine-registration module to align images.

Computed Tomography (CT) scans provide a high-resolutionimage of the lungs, allowing clinicians to identify the severity of infections in COVID-19 patients. This paper presents a domain knowledge-based pipeline for extracting infection regions from COVID-19 patients using a combination of image processing algorithms and a pre-trained UNET model. Then, an infection rate-based feature vector is generated for each CT scan.

Due to the scarcity of labeled data, Contrastive Self-Supervised Learning (SSL) frameworks have lately shown great potential in several medical image analysis tasks. However, the existing contrastive mechanisms are sub-optimal for dense pixel-level segmentation tasks due to their inability to mine local features. To this end, we extend the concept of metric learning to the segmentation task, using a dense (dis)similarity learning for pre-training a deep encoder network, and employing a semi-supervised paradigm to fine-tune for the downstream task.

Due to the scarcity of labeled data, Contrastive Self-Supervised Learning (SSL) frameworks have lately shown great potential in several medical image analysis tasks. However, the existing contrastive mechanisms are sub-optimal for dense pixel-level segmentation tasks due to their inability to mine local features. To this end, we extend the concept of metric learning to the segmentation task, using a dense (dis)similarity learning for pre-training a deep encoder network, and employing a semi-supervised paradigm to fine-tune for the downstream task.

The success of supervised deep learning heavily depends on large labeled datasets whose construction is often challenging in medical image analysis. Contrastive learning, a variant of self-supervised learning, is a potential solution to alleviate the strong demand for data annotation. In this work, we extend the contrastive learning framework to 3D volumetric medical imaging.