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Spike sorting is the process of assigning each detected neuronal spike in an extracellular recording to its putative source neuron. A linear filter design is proposed where the filter output allows for threshold-based spike sorting of high-density neural probe data. The proposed filter design is based on optimizing the signal-to-peak-interference ratio for each detectable neuron in a data-driven way.


EEG-based authentication is an emerging research field. In this work, a realistic authentication system using Electroencephalography signals, was developed aiming to show that brain signals contain sufficient information to be used in security systems. The dataset used was composed of 29 users on 4 different days via the cheap Neurosky Mindwave headset with a single dry electrode, and 10 users on 3 different days via Emotiv with 14 electrodes. Various techniques, features, and algorithms were examined to achieve the highest security.


The brain encodes information by neural spiking activities, which can be described by time series data as spike counts. Latent Vari- able Models (LVMs) are widely used to study the unknown factors (i.e. the latent states) that are dependent in a network structure to modulate neural spiking activities. Yet, challenges in performing experiments to record on neuronal level commonly results in rela- tively short and noisy spike count data, which is insufficient to de- rive latent network structure by existing LVMs. Specifically, it is difficult to set the number of latent states.


Recent work on resting-state functional magnetic resonance imaging (rs-fMRI) suggests that functional connectivity (FC) is dynamic. A variety of machine learning and signal processing tools have been applied to the study of dynamic functional connectivity networks (dFCNs) of the brain, by identifying a small number of network states that describe the dynamics of connectivity during rest. Recently, deep learning (DL) methods have been applied to neuroimaging data for learning generative models.


Identification of cell subclasses using single-cell RNA-Sequencing (scRNA-Seq) data is of paramount importance since it uncovers the hidden biological processes within the cell population. While the nonnegative matrix factorization (NMF) model has been reported to be effective in various unsupervised clustering tasks, it may still produce inappropriate results for some scRNA-Seq datasets with heterogeneous structures. In this paper, we propose the use of an orthogonally constrained NMF (ONMF) model for the subclass identification problem of scRNA-Seq datasets.


Presence of interictal epileptiform discharges (IED) in the electroencephalogram (EEG) is indicative of epilepsy. Automated
software for annotating EEGs of Patients with suspected epilepsy is substantial for diagnosis and management of epilepsy.
A large amount of data is needed for training and evaluating the performance of an effective IED detection system. IEDs occur
infrequently in the EEG of most patients, hence, interictal EEG recordings contain mostly background waveforms. As the first


The hyperscanning method simultaneously acquires and relates
cerebral data from two participants while performing
cooperative activities. The aim of this work is to evaluate
the performance of our novel EEG recording concept,
termed ear-EEG, against on-scalp EEG as an alternative,
user-friendly data acquisition approach for hyperscanning, in
the task of identifying the most robust, EEG subbands for
inter-individual neuronal synchrony detection in cooperative
multi-player gaming. This is achieved through the estimation


Parkinson’s disease (PD) produces several speech impairments in the patients. Automatic classification of PD patients is performed considering speech recordings collected in non- controlled acoustic conditions during normal phone calls in a unobtrusive way. A speech enhancement algorithm is applied to improve the quality of the signals. Two different classification approaches are considered: the classification of PD patients and healthy speakers and a multi-class experiment to classify patients in several stages of the disease.


One of the common modalities for observing mental activity is electroencephalogram (EEG) signals. However, EEG recording is highly susceptible to various sources of noise and to inter-subject differences. In order to solve these problems, we present a deep recurrent neural network (RNN) architecture to learn robust features and predict the levels of the cognitive load from EEG recordings. Using a deep learning approach, we first transform the EEG time series into a sequence of multispectral images which carries spatial information.