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In this study we investigate whether or not event-related (de)synchronisation (ERD/ERS) can be used to differenti- ate between 27 healthy elderly, 21 subjects diagnosed with amnestic mild cognitive impairment (aMCI) and 16 mild Alzheimer’s disease (AD) patients. Using 32-channel EEG recordings, we measured ERD responses to a three-level vi- sual N-back task (N = 0, 1, 2) on the well-known delta, theta, alpha, beta and gamma bands.


Atrial fibrillation (AF) patients need long-term electrocardiography (ECG) monitoring to detect occurrence of AF. We can acquire ECG signals under low power by compressive sensing based sensor and detect AF by existing algorithms. However, the compression ratio of AF signal is low when DWT basis is applied for CS reconstruction. On the other hand the complexity of AF detection algorithms is high. In this paper, we propose a CS-based ECG monitoring system with effective AF detection. We exploit dictionary learning to improve 2.5x better compression ratio than existing works.


In this paper, we propose a novel sparse common spatial pattern (CSP) algorithm to optimally select channels of EEG signals. Compared to the traditional CSP, which maximizes the variance of signals in one class and minimizes the variance of signals in the other class,the classification accuracy is guaranteed by a constraint that the ratio
of variances of signals in two different classes is lower bounded.Then, a sparse spatial filter is achieved by minimizing the l1-norm of filter coefficients and channels of EEG signals can be further optimized.


Objective: Common biological measurements are in
the form of noisy convolutions of signals of interest with possibly
unknown and transient blurring kernels. Examples include EEG
and calcium imaging data. Thus, signal deconvolution of these
measurements is crucial in understanding the underlying biological
processes. The objective of this paper is to develop fast and
stable solutions for signal deconvolution from noisy, blurred and
undersampled data, where the signals are in the form of discrete


Cancers originating from different organs can show similar genomic alterations whereas cancers originating from the same organ can vary across patients. Therefore cancer stratification that does not depend on the tissue of the origin can play an important role to better understand cancers having similar genomic patterns irrespective of their origins. In this work, we formulated the problem as a weighted graph and communities were found using a modularity maximization based graph clustering method. We classified 3,199 subjects from twelve different cancer types into five clusters.


In this dissertation, we propose the first, to the best of our knowledge, PCA based algorithm to noninvasively recognize and classify different temporal stages of brain tumors given a large time series of MRI images. We propose an algorithm that addresses the challenging task of classifying stage of tumor over period of time while the tumor is being treated with VB-111 virotherapy. Our approach treats stage tumor recognition as a two-dimensional recognition problem.